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Tell your healthcare provider if you have abused or been dependent on alcohol, prescription medicines or street drugs. • It is not known if diazepam tablets are safe and effective in children under 6 months of age. • It is not known if diazepam tablets are safe and effective for use longer than 4 months. Some loss of response to the effects of benzodiazepines may develop after repeated use of diazepam tablets for a prolonged time. Hypotension, respiratory depression and apnoea requiring appropriate counter measures (ventilation, cardiovascular support).
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It should be used with caution in patients with a history of seizures, head injury, or chronic benzodiazepine use. Contraindications to the use of flumazenil include features suggestive of a tricyclic antidepressant ingestion including a wide QRS, or large pupils. Use in patients postcardiac arrest is also contraindicated. Gastric lavage is unnecessary if these drugs have been taken alone. Patients who are asymptomatic at four hours are unlikely to develop symptoms. Studies in animals have shown a decrease in pregnancy rate and reduced number of surviving offspring in rats at high doses.
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Because of isolated reports of neutropenia and jaundice, periodic blood counts and buy xanax without prescrition liver function tests are advisable during long-term therapy. The background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated risk of major birth defects and of miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively.

You're more likely to get addicted if you need to take a higher dose for a longer time, or if you've ever had problems with alcohol or drugs. Yes, there is a risk of dependence when taking Diazepam long-term. It should be used under the guidance of a healthcare professional. If you do not understand whatyou are being given then ask your doctor or nurse. How long you'll need to take diazepam for depends on why you're taking it. It is usually only recommended for a short period of time of up to 4 weeks.
When used concurrently, side effects and toxicity may be more evident, particularly with hydantoins (eg phenytoin) and/or barbiturates. This requires extra care in adjusting dosage in the initial stages of treatment. Patients who have received benzodiazepines for a long time may require an extended withdrawal period. There is a potentially relevant interaction between diazepam and compounds which inhibit certain hepatic enzymes (particularly cytochrome P450 3A and 2C19). Data indicate that these compounds influence the pharmacokinetics of diazepam and may lead to increased and prolonged sedation. At present, this reaction is known to occur with cimetidine, ketoconazole, fluvoxamine, fluoxetine, and omeprazole.
Isoniazid inhibits the CYP2C19 and CYP3A4 metabolic pathway for diazepam. Co administration with 90 mg isoniazid twice daily for 3 days resulted in a prolonged elimination half-life of diazepam and in a 35% increased plasma concentration (AUC) of diazepam. • See "What is the most important information I should know about diazepam tablets? Taking diazepam tablets with other medicines used to treat epilepsy can cause an increase in the number or severity of grand mal seizures. • Diazepam tablets can make you sleepy or dizzy, and can slow your thinking and motor skills. • Take diazepam tablets exactly as your healthcare provider tells you to take them.