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This metabolite has a PDE selectivity profile like to sildenafil citrate and an in vitro authorisation for PDE5 or so 50% of the raise dose. Plasma concentrations of this metabolite are some 40% of those seen for sildenafil, so that the metabolite accounts for approximately 20% of sildenafil’s medicine personal effects. In cases of overdose, stock supportive measures should be adoptive as required. Nephritic dialysis is not potential to speed headway as sildenafil citrate is extremely restrain to plasm proteins and it is non eliminated in the water.
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