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26 November 2025

  • curprev 17:1517:15, 26 November 2025 LesliGairdner talk contribs 9,205 bytes +9,205 Created page with "<br><br><br>健康志愿者人群药动学研究显示,依法维伦等弱CYP诱导剂对DLM的体内暴露无影响。 DLM与强P450酶抑制作用的利托那韦联用时体内暴露量上升25%。 本品为半衰期较长的口服常释制剂,根据指导原则[11]的推荐,对于药物分布和清除个体内变异较小的药物,可用AUC0-72hr来代替AUC0-t或AUC0-∞。 考虑本品个药指导原则推荐两周期交叉设计,推测其非个体内高变..."