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<br><br><br>In the study of 10 mg tadalafil for 6 months and the study of 20 mg tadalafil for 9 months, results showed a decrease in mean sperm concentrations relative to placebo, although these differences were not clinically meaningful. This effect was not seen in the study of 20 mg tadalafil taken for 6 months. In addition there was no adverse effect on mean concentrations of reproductive hormones, testosterone, luteinizing hormone or follicle stimulating hormone with either 10 or 20 mg of tadalafil compared to placebo. A study was conducted to assess the interaction of sustained-release metoprolol (25 to 200 mg daily) and  BUY XANAX WITHOUT PRESCRITION tadalafil 10 mg. Following dosing, the mean reduction in supine systolic/diastolic blood pressure due to tadalafil 10 mg in subjects taking metoprolol was 5/3 mm Hg, compared to placebo. A study was conducted to assess the interaction of enalapril (10 to 20 mg daily) and tadalafil10 mg.<br>Treatment<br>Patients who get back pain and muscle aches usually get them 12 to 24 hours after taking Cialis and these usually go away by themselves within 48 hours. A small number of patients taking Cialis also reported abnormal vision. If you’re 70 years old, your doctor will likely start you on a low dosage of Cialis. If it works well for you, you’ll probably continue taking a low dosage. If it doesn’t work well for you or you develop bothersome side effects, your doctor will adjust your dosage.<br>Like most drugs, Cialis can cause an allergic reaction in some people. But it’s not clear whether this side effect occurred in the drug’s studies. Medicines are sometimes prescribed for conditions other than those described in patient information leaflets. Do not use CIALIS for a condition  for which it was not prescribed. Do not give CIALIS to other people, even if they have the same symptoms that you have.<br>Serious side effects of Cialis<br>You don’t have to take Cialis at any specific time before sexual activity when it’s prescribed in this way. This helps make sure there’s enough medication in your body for Cialis to be effective. For treating ED, your doctor may prescribe a Cialis dosage for daily use of 5 mg once per day. You do not have to take Cialis at any specific time before sexual activity when it’s prescribed in this way. You also should not take more than the recommended maximum dosage of Cialis, which is 20 mg per day.<br><br>If you take Cialis daily for ED, benign prostatic hyperplasia (BPH), or both ED and BPH, you can take your dose at any time of day. But you should try to take your dose at the same time every day. It’s important to not take more Cialis than the dose your doctor recommends. If you have other questions about Cialis doses, talk with your doctor or pharmacist. Whichever condition Cialis is used to treat, the recommended maximum dose per day is 20 mg.<br>A similar study reported a consistent result, with a risk estimate of 2.27 (95% CI0.99, 5.20). Other risk factors for NAION, such as the presence of "crowded" optic disc, may have contributed to the occurrence of NAION in these studies. Evaluation of erectile dysfunction and BPH should include an appropriate medical assessment to identify potential underlying causes, as well as treatment options. Ketoconazole (400 mg daily), a selective and potent inhibitor of CYP3A4,increased tadalafil 20 mg single-dose exposure (AUC) by 312% and Cmax by 22%, relative to the values for tadalafil 20 mg alone. Ketoconazole (200 mg daily) increased tadalafil 10-mg single-dose exposure (AUC) by107% and Cmax by 15%, relative to the values for tadalafil 10 mg alone [see DOSAGE AND ADMINISTRATION] .<br>Steady-state plasma concentrations are attained within 5 days of once per day dosing and exposure is approximately 1.6-fold greater than after a single dose. The effects of tadalafil on cardiac function, hemodynamics, and exercise tolerance were investigated in a single clinical pharmacology study. In this blinded crossover trial, 23 subjects with stable coronary artery disease and evidence of exercise-induced cardiac ischemia were enrolled. The mean difference in total exercise time was 3 seconds (tadalafil 10 mg minus placebo), which represented no clinically meaningful difference. Further statistical analysis demonstrated that tadalafil was non-inferior to placebo with respect to time to ischemia.<br><br>